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KMID : 0358920050320030499
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Journal of the Korean Academy of Pedodontics
2005 Volume.32 No. 3 p.499 ~ p.508
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EFFECT OF ADMINSTRATION METHOD OF FLUMAZENIL ON THE PLASMA CONCENTRATION AND THE REVERSAL OF SEDATION INDUCED BY MIDAZOLAM
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Park Seong-Kyu
Lee Sang-Ho
Lee Chang-Seep
Lee Nan-Young
Oh You-Hyang
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Abstract
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The purpose of this study were to evaluate the effect on the reversion of sedation induced by midazolam with flumazenil and to determine the plasma concentration of flumazenil according to the method of administration.
Intranasal and intravenous flumazenil were administered to sedated health volunteers aged from 23 to 25 years, in doses typical of those used clinically to induce sedation with midazolam and for reversal with flumazenil. Objective assessment for degree of sedation and vital signs, plasma concentration were made for 2 hours period.
1. Systolic and diastolic blood pressure, SpO₂ were not changed by adminstration of flumazenil in sedated subject with midazolam, but pulse rate was increased temporarily.
2. Flumazenil showed the reversal of the sedative effect induced by midazolam regardless of administration methods. But intravenous administration showed more effect on the degree and the duration of reversion than intranasal administration with the exception of on set time.
3. Peak plasma concentration of flumazenil administered by intranasal route reached after 2 min and that of flumazenil administered by intravenous route was 4 min. Thus uptake of flumazenil did not showed any difference in accordance with the adminstration route.
4. Administration of flumazenil resulted in the temporary increase of midazolam plasma concentration.
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KEYWORD
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Flumazenil, Midazolam, Sedation, Antagonic effect, Vital sign
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